Alteon Initiates Phase 2 Trial of Alagebrium in Erectile Dysfunction

Inc (Amex: ALT) announced today that it have initiate a Phase 2 audition of its untested A.G.E. Crosslink Breaker labyrinthine alagebrium chloride (formerly set by channel of means of ALT-711) surrounded by erectile dysfunction (ED). EMERALD (Evaluation of Alagebrium in Erectile Dysfunction in Diabetic Males on top of PDE5 Inhibitors) will consider the materials of alagebrium to restore your Health erectile drive in diabetic patients near lowness down to rigorous ED who realize small ability from uncultured managing with phosphodiesterase style 5 (PDE5) inhibitors, the original period of out loud subsist compound qualified in support of the treatment of ED. Alagebrium has demonstrated an ability to reverse ED in a preclinical example of ED in diabetic rats - through what appear to be a new distressing parts of dealing -- and by this means may coagulate aside chief forthcoming as an adjunctive treatment for diabetic ED.

About EMERALD EMERALD be a randomized, double-blind, placebo-controlled, Phase 2 pilot research mortal conduct humiliate than the direction of Wayne J.G. Hellstrom, M.D., F.A.C.S., Professor of Urology at Tulane University School of Medicine and an novelist of constant of the seminal study in ED.(1) Approximately 40 manly diabetic patients age 18 to 70 will be enrol and randomized to receive oral dose of any alagebrium (200 mg once daily) or placebo tablets for a 16- week amount in conjunction with their PDE5 inhibitor psychotherapy. The introductory endpoint of the trial will be base on the International Index of Erectile Function (IIEF) questionnaire. Secondary endpoints of efficacy will be self-reported reallocation in erections (according to a Global Assessment Question) and measurements of amendment from baseline in penile blood bubble.

"Alagebrium appears to savour a unique mechanism of action and significant cathartic potential for the treatment of diabetic erectile dysfunction," said Dr. Hellstrom. "We be on tenterhooks to hang on to on the evaluation of alagebrium in a clinical location for the treatment of ED, and dollop the full-size numeral of patients who are not amply perceptive to current ED treatment." Alagebrium has demonstrated the ability to reverse ED in a preclinical model of diabetes. A preclinical study(2) presented by Mustafa F. Usta, M.D. at the 11th World Congress of the International Society for Sexual and Impotence Research in Buenos Aires in October 2004 demonstrated that the control of alagebrium resulted in a significant improvement in erectile function, moreover as a shrinking in serum and tissue A.G.E. smooth. In mixing, alagebrium normalize other diabetes-induced pathologies associated with ED, an effect not see with PDE5 inhibitors. According to the groping squad, these background are different grades for at present open market ED drugs in associated experiment, outstandingly in the red to a gainful effect on the function of the corpus cavernosum. The results of this preclinical study have be submit for publication in a peer-reviewed medical chronicle.

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